How To Get Pregnant with Endometriosis

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How to Get Pregnant with Endometriosis

Main article: Endometriosis Overview

Updated: 16-August-2024

How to get pregnant with Endometriosis

Women with endometriosis can become pregnant naturally or with medical assistance. Even though up to 40% of women with endometriosis are diagnosed with infertility,1 the majority of women fall pregnant naturally in spite of endometriosis.

For this reason, doctors usually recommend women try to conceive naturally for at least 6 or more months so long as their menstrual cycles are regular and no other known causes of infertility (male or female) exist.

However, if the couple are still unsuccessful after 6 to 12 months, the doctor will suggest medically assisted reproduction.

Natural Conception with Endometriosis

Many women with endometriosis are able to get pregnant naturally which means expectant management (i.e. watchful waiting) may be a viable option.

However, women should consider the following beforehand:

  • Age
  • Comorbidities
  • Pain
  • Ovulation
  • Fallopian tube patency
  • Endometrial receptivity
  • Sperm quality
  • Diet
  • Supplements

Age

According to the Endometriosis Fertility Index, women with endometriosis do not experience a natural decline in fertility until the age of 35.2 This suggests the majority of women 30 years of age or younger with endometriosis can try to conceive naturally without worrying about their body clock.

However the natural fecundity (fertility) rate per month for women with endometriosis is significantly less than normal, between 2-10% depending on severity.3 This means it could take some women several years or longer to fall pregnant naturally which can strain the couples relationship. The only exception to this is rectosigmoid endometriosis, where 3 in 4 women conceive naturally in a median time of 10 months (range 2 to 34 months).4

Nevertheless, it’s also worth remembering that women with endometriosis experience natural menopause earlier than women without endometriosis.5,6,7 Consequently, women 35 years of age or older with endometriosis have lower levels of AMH (ovarian reserve) compared to women without endometriosis which is known to decrease IVF success rates per cycle.8,9

References

  1. Strathy J H, et al. (1982). Endometriosis and infertility: a laparoscopic study of endometriosis among fertile and infertile women. https://www.sciencedirect.com/science/article/pii/S0015028216466914 ↩︎
  2. Adamson G D, et al. (2010). Endometriosis fertility index: the new, validated endometriosis staging system. https://www.fertstert.org/article/S0015-0282(09)03714-5/fulltext ↩︎
  3. Practice Committee of the American Society for Reproductive Medicine, (2012). Endometriosis and infertility: a committee opinion. https://www.fertstert.org/article/S0015-0282(12)00585-7/fulltext ↩︎
  4. Ferrero S, et al. (2020). Fertility in patients with untreated rectosigmoid endometriosis. https://www.rbmojournal.com/article/S1472-6483(20)30639-8/abstract ↩︎
  5. Kulkarni M T, et al. (2022). Association Between Laparoscopically Confirmed Endometriosis and Risk of Early Natural Menopause. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788287 ↩︎
  6. Yasui T, et al. (2011). Association of endometriosis-related infertility with age at menopause. https://www.maturitas.org/article/S0378-5122(11)00145-9/abstract ↩︎
  7. Pokoradi A, et al. (2011). Factors associated with age of onset and type of menopause in a cohort of UK women. https://www.ajog.org/article/S0002-9378(11)00249-3/abstract ↩︎
  8. Farland L V, et al. (2024). Laparoscopically confirmed endometriosis and anti-Müllerian hormone levels: Findings from the Nurses’ Health Study II. https://www.maturitas.org/article/S0378-5122(24)00064-1/abstract ↩︎
  9. Liu S, et al. (2023). Influence of ovarian reserves on assisted reproductive and perinatal outcomes in patients with endometriosis: a retrospective study. https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1084927/full ↩︎
  10. Don E E, et al. (2023). Infertility in patients with uterine fibroids: a debate about the hypothetical mechanisms. https://academic.oup.com/humrep/article/38/11/2045/7285837 ↩︎
  11. Uimari O, et al. (2021). Endometriosis and Uterine Fibroids (Leiomyomata): Comorbidity, Risks and Implications. https://www.frontiersin.org/journals/reproductive-health/articles/10.3389/frph.2021.750018/full ↩︎
  12. Zheng Q M, et al. (2015). Risk of endometrial polyps in women with endometriosis: a meta-analysis. https://rbej.biomedcentral.com/articles/10.1186/s12958-015-0092-2 ↩︎
  13. Jee B C and Jeong H G, (2021). Management of endometrial polyps in infertile women: A mini-review. https://ecerm.org/journal/view.php?doi=10.5653/cerm.2020.04119 ↩︎
  14. Kobayashi H, et al. (2023). Similarities in Pathogenetic Mechanisms Underlying the Bidirectional Relationship between Endometriosis and Pelvic Inflammatory Disease. https://www.mdpi.com/2075-4418/13/5/868 ↩︎
  15. Jennings L K, et al. (2023). Pelvic Inflammatory Disease. https://www.ncbi.nlm.nih.gov/books/NBK499959/ ↩︎
  16. Cicinelli E, et al. (2017). Higher prevalence of chronic endometritis in women with endometriosis: a possible etiopathogenetic link. https://www.fertstert.org/article/S0015-0282(17)30397-7/fulltext ↩︎
  17. Cicinelli E, et al. (2017). Chronic endometritis in patients with unexplained infertility: Prevalence and effects of antibiotic treatment on spontaneous conception. https://onlinelibrary.wiley.com/doi/full/10.1111/aji.12782 ↩︎
  18. Chiaffarino F, et al. (2021). Endometriosis and inflammatory bowel disease: A systematic review of the literature. https://www.ejog.org/article/S0301-2115(20)30426-7/abstract ↩︎
  19. Druvefors E, et al. (2021). Impaired Fertility in Women With Inflammatory Bowel Disease: A National Cohort Study From Sweden. https://academic.oup.com/ecco-jcc/article/15/3/383/5908862 ↩︎
  20. Korošec S, et al. (2024). Coexistence of Endometriosis and Thyroid Autoimmunity in Infertile Women: Impact on in vitro Fertilization and Reproductive Outcomes. https://karger.com/goi/article/doi/10.1159/000539265/907088/Coexistence-of-Endometriosis-and-Thyroid ↩︎
  21. Abalovich M, et al. (2006). Subclinical hypothyroidism and thyroid autoimmunity in women with infertility. https://www.tandfonline.com/doi/full/10.1080/09513590701259542 ↩︎
  22. Chen S F, et al. (2021). Risk of Rheumatoid Arthritis in Patients with Endometriosis: A Nationwide Population-Based Cohort Study. https://www.liebertpub.com/doi/10.1089/jwh.2020.8431 ↩︎
  23. Brouwer J, et al. (2015). Fertility in women with rheumatoid arthritis: influence of disease activity and medication. https://ard.bmj.com/content/74/10/1836 ↩︎
  24. Tajik M, et al. (2022). The co-effect of sensate focus technique and sexual position changing on sexual function of women who use medical treatment for endometriosis. https://www.tandfonline.com/doi/full/10.1080/01443615.2022.2158316 ↩︎
  25. Badawy S Z, et al. (1981). Ovulatory dysfunction in patients with endometriosis. https://pubmed.ncbi.nlm.nih.gov/7338159/ ↩︎
  26. Kaya H and Oral B, (1999). Effect of ovarian involvement on the frequency of luteinized unruptured follicle in endometriosis. https://karger.com/goi/article-abstract/48/2/123/151835/Effect-of-Ovarian-Involvement-on-the-Frequency-of ↩︎
  27. Mio Y, et al. (1992). Luteinized unruptured follicle in the early stages of endometriosis as a cause of unexplained infertility. https://www.ajog.org/article/S0002-9378(11)91673-1/abstract ↩︎
  28. Toda T, (1990). [Ultrasonographical study on luteinized unruptured follicle]. https://pubmed.ncbi.nlm.nih.gov/2212820/ ↩︎
  29. Santulli P, et al. (2018). Oligo-anovulation is not a rarer feature in women with documented endometriosis. https://www.fertstert.org/article/S0015-0282(18)30488-6/fulltext ↩︎
  30. Schliep K C, et al. (2023). Examining the co-occurrence of endometriosis and polycystic ovarian syndrome. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472311/ ↩︎
  31. Zheng X, et al. (2021). Prevalence of subtle distal Fallopian tube abnormalities and their association with endometriosis in infertility patients: a prospective cohort study. https://www.tandfonline.com/doi/full/10.1080/14647273.2021.1981551 ↩︎
  32. Nicolaus K, et al. (2020). A two-third majority of infertile women exhibit endometriosis in pre-ART diagnostic hysteroscopy and laparoscopic chromopertubation: only one-third have a tubal obstruction. https://link.springer.com/article/10.1007/s00404-020-05479-5 ↩︎
  33. Mayrhofer D, et al. (2022). Are the Stage and the Incidental Finding of Endometriosis Associated with Fallopian Tube Occlusion? A Retrospective Cohort Study on Laparoscopic Chromopertubation in Infertile Women. https://www.mdpi.com/2077-0383/11/13/3750 ↩︎
  34. Izumi G, et al. (2017). Oil-Soluble Contrast Medium (OSCM) for Hysterosalpingography Modulates Dendritic Cell and Regulatory T Cell Profiles in the Peritoneal Cavity: A Possible Mechanism by Which OSCM Enhances Fertility. https://journals.aai.org/jimmunol/article/198/11/4277/106113/Oil-Soluble-Contrast-Medium-OSCM-for ↩︎
  35. Johnson N P, et al. (2013). Review of lipiodol treatment for infertility – an innovative treatment for endometriosis-related infertility? https://obgyn.onlinelibrary.wiley.com/doi/10.1111/ajo.12141 ↩︎
  36. Court K A, et al. (2014). Establishment of lipiodol as a fertility treatment – Prospective study of the complete innovative treatment data set. https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1111/ajo.12124 ↩︎
  37. Johnson N P, et al. (2004). The FLUSH Trial—Flushing with Lipiodol for Unexplained (and endometriosis-related) Subfertility by Hysterosalpingography: a randomized trial. https://academic.oup.com/humrep/article/19/9/2043/782329 ↩︎
  38. Lo G, et al. (2024). Ultrasound-guided Lipiodol® hysterosalpingography: A prospective study on pregnancy and complication rates. https://obgyn.onlinelibrary.wiley.com/doi/10.1111/ajo.13794 ↩︎
  39. Matthews D M, et al. (2022). The SELFI Study: Iodine Excess and Thyroid Dysfunction in Women Undergoing Oil-Soluble Contrast Hysterosalpingography. https://academic.oup.com/jcem/article/107/12/3252/6704756 ↩︎
  40. Burney R O, et al. (2007). Gene Expression Analysis of Endometrium Reveals Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis. https://academic.oup.com/endo/article/148/8/3814/2502189 ↩︎
  41. Ali R, et al. (2023). An interplay of Progesterone, Leukemia Inhibitor Factor and Interleukin-6 in the window of implantation; Impact on fertility. https://www.sciencedirect.com/science/article/pii/S1043466623002107 ↩︎
  42. Budihastuti U R, et al. (2023). Endometrial receptivity defects MUC-1 and COX-2 polymorphisms in endometriosis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10835549/ ↩︎
  43. Yang S C, et al. (2023). CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis. https://www.nature.com/articles/s41467-023-39008-0 ↩︎
  44. Yoo J Y, et al. (2022). Loss of MIG-6 results in endometrial progesterone resistance via ERBB2. https://www.nature.com/articles/s41467-022-28608-x ↩︎
  45. Tang X, et al. (2021). NR4A1 Affects Endometrial Receptivity by Participating in Mesenchymal–Epithelial Transition of Endometrial Stromal Cells. https://link.springer.com/article/10.1007/s43032-021-00792-z ↩︎
  46. Kim T H, et al. (2021). Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium. https://academic.oup.com/jcem/article/107/3/788/6403385 ↩︎
  47. Schmitz C R, et al. (2017). Alterations in expression of endometrial milk fat globule-EGF factor 8 (MFG-E8) and leukemia inhibitory factor (LIF) in patients with infertility and endometriosis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714598/ ↩︎
  48. Petousis S, et al. (2018). Unexplained infertility patients present the mostly impaired levels of progesterone receptors: Prospective observational study. https://onlinelibrary.wiley.com/doi/full/10.1111/aji.12828 ↩︎
  49. Margioula-Siarkou C, et al. (2017). LIF endometrial expression is impaired in women with unexplained infertility while LIF-R expression in all infertility sub-groups. https://www.sciencedirect.com/science/article/pii/S1043466617300947 ↩︎
  50. Alsbjerg B, et al. (2022). Endometriosis patients benefit from high serum progesterone in hormone replacement therapy–frozen embryo transfer cycles: a cohort study. https://www.rbmojournal.com/article/S1472-6483(22)00696-4/fulltext ↩︎
  51. Cheng J, et al. (2022). Metformin Alleviates Endometriosis and Potentiates Endometrial Receptivity via Decreasing VEGF and MMP9 and Increasing Leukemia Inhibitor Factor and HOXA10. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.750208/full ↩︎
  52. Wang L, et al. (2021). Low-dose aspirin can downregulate progesterone resistance and increase the expression of LIF in endometriosis during the implantation window. https://www.tandfonline.com/doi/full/10.1080/09513590.2021.1918663 ↩︎
  53. Foda A and Aal I, (2012). Metformin as a new therapy for endometriosis, its effects on both clinical picture and cytokines profile. https://www.sciencedirect.com/science/article/pii/S1110569012000957 ↩︎
  54. Piróg M, et al. (2021). Fibrin clot properties among women with endometriosis and the impact of ovarian stimulation. https://www.rbmojournal.com/article/S1472-6483(21)00109-7/abstract ↩︎
  55. Schatz F, et al. (2016). The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding. https://academic.oup.com/humupd/article/22/4/497/2573341 ↩︎
  56. Orazov M R, et al. (2021). Endometrial asynchrony in pathogenesis of implantation impairment in women with infertility associated with endometriosis. https://www.tandfonline.com/doi/full/10.1080/09513590.2021.2006437 ↩︎
  57. Zhang Z, et al. (2024). Vaginal extracellular vesicles impair fertility in endometriosis by favoring Th17/Treg imbalance and inhibiting sperm activity. https://onlinelibrary.wiley.com/doi/10.1002/jcp.31188 ↩︎
  58. Pillai S, et al. (2011). Effects of Antibodies to Transferrin and Alpha 2-HS Glycoprotein on In Vitro Sperm Motion: Implications in Infertility Associated with Endometriosis. https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.1998.tb00359.x ↩︎
  59. Faber B M, et al. (2001). Macrophage secretory products and sperm zona pellucida binding. https://www.sciencedirect.com/science/article/abs/pii/S0029784401015101 ↩︎
  60. Aeby T C, et al. (1996). The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro. https://www.ajog.org/article/S0002-9378(96)70210-7/abstract ↩︎
  61. Wang S, et al. (2023). Noninvasive electrophysiological imaging identifies 4D uterine peristalsis patterns in subjects with normal menstrual cycles and patients with endometriosis. https://www.researchsquare.com/article/rs-2432192/v1 ↩︎
  62. Shivappa N, et al. (2014). Designing and developing a literature-derived, population-based dietary inflammatory index. https://www.cambridge.org/core/journals/public-health-nutrition/article/designing-and-developing-a-literaturederived-populationbased-dietary-inflammatory-index/30BE2C2295CE93DC6B54F9F9AD50CC68 ↩︎
  63. Herup-Wheeler T, et al. (2023). High-fat diets promote peritoneal inflammation and augment endometriosis-associated abdominal hyperalgesia. https://www.biorxiv.org/content/10.1101/2023.11.09.566474v1.full ↩︎
  64. Shafrir A L, et al. (2018). Risk for and consequences of endometriosis: A critical epidemiologic review. https://www.sciencedirect.com/science/article/pii/S1521693418301093 ↩︎
  65. Chadchan S B, et al. (2021). Gut microbiota–derived short-chain fatty acids protect against the progression of endometriosis. https://www.life-science-alliance.org/content/4/12/e202101224 ↩︎
  66. Kyozuka H, et al. (2021). Prepregnancy antiinflammatory diet in pregnant women with endometriosis: The Japan Environment and Children’s Study. https://www.sciencedirect.com/science/article/pii/S0899900720304147 ↩︎
  67. Mc Cormack B A, et al. (2021). Effect of urolithins A and B on ectopic endometrial growth in a murine model of endometriosis. https://pubs.rsc.org/en/content/articlelanding/2021/fo/d1fo01702k ↩︎
  68. Singh A, et al. (2021). Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. https://www.nature.com/articles/s41430-021-00950-1 ↩︎
  69. Monastra G, et al. (2018). Vitamin D: a steroid hormone with progesterone-like activity. https://www.europeanreview.org/article/14845 ↩︎
  70. Delbandi A A, et al. (2020). Vitamin D deficiency as a risk factor for endometriosis in Iranian women. https://www.sciencedirect.com/science/article/pii/S016503782030187X ↩︎
  71. Krishnan A V and Feldman D, (2011). Mechanisms of the Anti-Cancer and Anti-Inflammatory Actions of Vitamin D. https://www.annualreviews.org/content/journals/10.1146/annurev-pharmtox-010510-100611 ↩︎
  72. Matasariu D R, et al. (2023). Vitamin D and Mitosis Evaluation in Endometriosis: A Step toward Discovering the Connection? https://www.mdpi.com/2227-9059/11/8/2102 ↩︎
  73. Hu R, et al. (2023). 25(OH)D3 improves granulosa cell proliferation and IVF pregnancy outcomes in patients with endometriosis by increasing G2M+S phase cells. https://rbej.biomedcentral.com/articles/10.1186/s12958-023-01165-8 ↩︎
  74. Safari H, et al. (2022). Vitamin D and calcium, together and separately, play roles in female reproductive performance. https://www.nature.com/articles/s41598-022-14708-7 ↩︎
  75. Amini L, et al. (2021). The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial. https://onlinelibrary.wiley.com/doi/10.1155/2021/5529741 ↩︎
  76. Didziokaite G, et al. (2023). Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility. https://www.mdpi.com/1422-0067/24/4/3809 ↩︎
  77. Mier-Cabrera J, et al. (2008). Effect of vitamins C and E supplementation on peripheral oxidative stress markers and pregnancy rate in women with endometriosis. https://obgyn.onlinelibrary.wiley.com/doi/full/10.1016/j.ijgo.2007.08.018 ↩︎
  78. Dymanowska-Dyjak I, et al. (2024). Oxidative Imbalance in Endometriosis-Related Infertility—The Therapeutic Role of Antioxidants. https://www.mdpi.com/1422-0067/25/12/6298 ↩︎
  79. Porpora M G, et al. (2013). A Promise in the Treatment of Endometriosis: An Observational Cohort Study on Ovarian Endometrioma Reduction by N-Acetylcysteine. https://onlinelibrary.wiley.com/doi/10.1155/2013/240702 ↩︎
  80. Li G, et al. (2022). Endometrial stromal cell ferroptosis promotes angiogenesis in endometriosis. https://www.nature.com/articles/s41420-022-00821-z ↩︎
  81. Anastasi E, et al. (2023). Efficacy of N-Acetylcysteine on Endometriosis-Related Pain, Size Reduction of Ovarian Endometriomas, and Fertility Outcomes. https://www.mdpi.com/1660-4601/20/6/4686 ↩︎
  82. Becker C M, et al. (2022). ESHRE guideline: endometriosis. https://academic.oup.com/hropen/article/2022/2/hoac009/6537540 ↩︎
  83. Turco L C, et al. (2021). Near-Infrared Imaging With Indocyanine Green for the Treatment of Endometriosis: Results From the Gre-Endo Trial. https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.737938/full ↩︎
  84. Kanno K, et al. (2021). Clinical use of indocyanine green during nerve-sparing surgery for deep endometriosis. https://www.fertstert.org/article/S0015-0282(21)00219-3/fulltext ↩︎
  85. Chang F H, et al. (1997). Efficacy of isotopic 13CO2 laser laparoscopic evaporation in the treatment of infertile patients with minimal and mild endometriosis: A life table cumulative pregnancy rates study. https://www.sciencedirect.com/science/article/abs/pii/S1074380497800138 ↩︎
  86. Osmanlıoğlu Ş, et al. (2023). The size, number and bilaterality of endometriomas do not affect spontaneous conception chance following surgical removal. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10712823/ ↩︎
  87. Puscasiu L, et al. (2022). Pregnancy rate following endometriomas management by ablation using plasma energy, cystectomy and drainage: A three-arm comparative study. https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.14444 ↩︎
  88. Yeung P, et al. (2023). Fertility after expanded polytetrafluoroethylene use after endometrioma cystectomy: a pilot study. https://www.frontiersin.org/journals/reproductive-health/articles/10.3389/frph.2023.1231029/full ↩︎
  89. Tsolakidis D, et al. (2010). The impact on ovarian reserve after laparoscopic ovarian cystectomy versus three-stage management in patients with endometriomas: a prospective randomized study. https://www.fertstert.org/article/S0015-0282(09)00264-7/fulltext ↩︎
  90. Javaheri A, et al. (2021). Ovarian reserve in women with endometriosis under total cystectomy compared to partial cystectomy: A randomized clinical trial. https://knepublishing.com/index.php/ijrm/article/view/9472 ↩︎
  91. Baldini G M, et al. (2024). Can the endometrioma be an obstacle to complete oocyte retrieval in IVF cycles? A retrospective study. https://www.europeanreview.org/article/35911 ↩︎
  92. Vaduva C C, et al. (2023). Ovarian reserve after treatment of ovarian endometriomas by ethanolic sclerotherapy compared to surgical treatment. https://www.europeanreview.org/article/32795 ↩︎
  93. Marcoux S, et al. (1997). Laparoscopic Surgery in Infertile Women with Minimal or Mild Endometriosis. https://www.nejm.org/doi/full/10.1056/NEJM199707243370401 ↩︎
  94. Jacobson T Z, et al. (2010). Laparoscopic surgery for subfertility associated with endometriosis. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD001398.pub2/full ↩︎
  95. Sarbazi F, et al. (2021). The Clinical Outcome of Laparoscopic Surgery for Endometriosis on Pain, Ovarian Reserve, and Cancer Antigen 125 (CA-125): A Cohort Study. https://www.ijfs.ir/article_243659.html ↩︎
  96. Piriyev E, et al. (2022). Significance of Ki67 expression in endometriosis for infertility. https://www.ejog.org/article/S0301-2115(22)00251-2/abstract ↩︎
  97. Kondo W, et al. (2010). Complications after surgery for deeply infiltrating pelvic endometriosis. https://obgyn.onlinelibrary.wiley.com/doi/10.1111/j.1471-0528.2010.02774.x ↩︎
  98. Gracia M, et al. (2022). Adenomyosis is an independent risk factor for complications in deep endometriosis laparoscopic surgery. https://www.nature.com/articles/s41598-022-11179-8 ↩︎
  99. Raos M, et al. (2022). Impact of surgery on fertility among patients with deep infiltrating endometriosis. https://www.ejog.org/article/S0301-2115(22)00616-9/fulltext ↩︎
  100. Hezer S, et al. (2022). Fertility Outcomes after Surgical Management of Colorectal Endometriosis: A Single-center Retrospective Study. https://www.jmig.org/article/S1553-4650(22)01035-4/abstract ↩︎
  101. Rodríguez Y, et al. (2024). Management of patients with endometriosis and infertility: laparoscopic treatment and spontaneous pregnancy rate. https://pubmed.ncbi.nlm.nih.gov/38640351/ ↩︎
  102. Rad M T, et al. (2023). Pregnancy after laparoscopic surgery for endometriosis: How long should we wait? A retrospective study involving a long-term follow up at a university endometriosis center. https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.14849 ↩︎
  103. Leborne E, et al. (2022). Clinical outcomes following surgical management of deep infiltrating endometriosis. https://www.nature.com/articles/s41598-022-25751-9 ↩︎
  104. Bailleul A, et al. (2021). Infertility management according to the Endometriosis Fertility Index in patients operated for endometriosis: What is the optimal time frame? https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0251372 ↩︎
  105. Demir E, et al. (2022). Outcomes between non-IVF and IVF treatment after laparoscopic conservative surgery of advanced endometriosis with Endometriosis Fertility Index score >3. https://journals.lww.com/md-journal/fulltext/2022/09160/outcomes_between_non_ivf_and_ivf_treatment_after.96.aspx ↩︎
  106. Deng T, et al. (2023). Comparison of Dydrogesterone and GnRH-a Effects After Laparoscopic Surgery in Patients with Stage III and IV Endometriosis. https://www.dovepress.com/comparison-of-dydrogesterone-and-gnrh-a-effects-after-laparoscopic-sur-peer-reviewed-fulltext-article-IJGM ↩︎
  107. Pellicer N, et al. (2020). Use of dopamine agonists to target angiogenesis in women with endometriosis. https://academic.oup.com/humrep/article/36/4/850/6045346 ↩︎
  108. Gómez R, et al. (2011). Effects of hyperprolactinemia treatment with the dopamine agonist quinagolide on endometriotic lesions in patients with endometriosis-associated hyperprolactinemia. https://www.fertstert.org/article/S0015-0282(10)02700-7/fulltext ↩︎
  109. Creus M, et al. (2008). Combined laparoscopic surgery and pentoxifylline therapy for treatment of endometriosis-associated infertility: a preliminary trial. https://academic.oup.com/humrep/article/23/8/1910/2914066 ↩︎
  110. Tummon I S, et al. (1997). Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis. https://www.fertstert.org/article/S0015-0282(97)81467-7/fulltext ↩︎
  111. Werbrouck E, et al. (2006). No difference in cycle pregnancy rate and in cumulative live-birth rate between women with surgically treated minimal to mild endometriosis and women with unexplained infertility after controlled ovarian hyperstimulation and intrauterine insemination. https://www.fertstert.org/article/S0015-0282(06)00928-9/fulltext ↩︎
  112. Sarkar S, et al. (2022). Comparison of Treatment outcomes following Ovarian Stimulation with Intrauterine Insemination in Minimal or Mild Endometriosis versus Unexplained Infertility: A Retrospective Cohort Study. https://journals.lww.com/jhrs/fulltext/2022/15030/comparison_of_treatment_outcomes_following_ovarian.9.aspx ↩︎
  113. Zhou L, et al. (2021). Ovulation induction with clomiphene citrate or letrozole following laparoscopy in infertile women with minimal to mild endometriosis: a prospective randomised controlled trial. https://www.tandfonline.com/doi/full/10.1080/01443615.2021.1904224 ↩︎
  114. Zimmermann A, et al. (2023). Impact of moderate-to-severe endometriosis on IVF cumulative live birth rate: a retrospective matched cohort study. https://www.rbmojournal.com/article/S1472-6483(23)00123-2/abstract ↩︎
  115. Wang L, et al. (2022). High spontaneous pregnancy and live birth rate in patients with stage III-IV endometriosis following surgical management. https://www.sciencedirect.com/science/article/pii/S1015958421008411 ↩︎
  116. Bourdon M, et al. (2022). Presence of adenomyosis at MRI reduces live birth rates in ART cycles for endometriosis. https://academic.oup.com/humrep/article/37/7/1470/6573229 ↩︎
  117. Rees C O, et al. (2022). Women with combined adenomyosis and endometriosis on MRI have worse IVF/ICSI outcomes compared to adenomyosis and endometriosis alone: A matched retrospective cohort study. https://www.ejog.org/article/S0301-2115(22)00077-X/abstract ↩︎
  118. Hu R, et al. (2023). 25(OH)D3 improves granulosa cell proliferation and IVF pregnancy outcomes in patients with endometriosis by increasing G2M+S phase cells. https://rbej.biomedcentral.com/articles/10.1186/s12958-023-01165-8 ↩︎
  119. Vaiarelli A, et al. (2020). Endometriosis shows no impact on the euploid blastocyst rate per cohort of inseminated metaphase-II oocytes: A case-control study. https://www.ejog.org/article/S0301-2115(20)30735-1/abstract ↩︎
  120. Metzemaekers J, et al. (2021). Prognosis in fertilisation rate and outcome in IVF cycles in patients with and without endometriosis: a population-based comparative cohort study with controls. https://fvvo.eu/archive/volume-13/number-1/original-articles/prognosis-in-fertilisation-rate-and-outcome-in-ivf-cycles-in-patients-with-and-without-endometriosis ↩︎
  121. Robin C, et al. (2021). Impact of endometriosis on oocyte morphology in IVF-ICSI: retrospective study of a cohort of more than 6000 mature oocytes. https://rbej.biomedcentral.com/articles/10.1186/s12958-021-00798-x ↩︎
  122. Alsbjerg B, et al. (2023). Endometriosis patients benefit from high serum progesterone in hormone replacement therapy–frozen embryo transfer cycles: a cohort study. https://www.rbmojournal.com/article/S1472-6483(22)00696-4/fulltext ↩︎
  123. Huang L, et al. (2021). Low basal serum testosterone level is detrimental to the embryo implantation in the patients with severe endometriosis. https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/jog.14791 ↩︎
  124. Chern C U, et al. (2018). Dehydroepiandrosterone (DHEA) supplementation improves in vitro fertilization outcomes of poor ovarian responders, especially in women with low serum concentration of DHEA-S: a retrospective cohort study. https://link.springer.com/article/10.1186/s12958-018-0409-z ↩︎
  125. Zhong C, et al. (2021). Analysis of IVF/ICSI Outcomes in Endometriosis Patients With Recurrent Implantation Failure: Influence on Cumulative Live Birth Rate. https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.640288/full ↩︎
  126. Sallam H N, et al. (2006). Long‐term pituitary down‐regulation before in vitro fertilization (IVF) for women with endometriosis. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD004635.pub2/full ↩︎
  127. Alson S, et al. (2024). Endometriosis diagnosed by ultrasound is associated with lower live birth rates in women undergoing their first in vitro fertilization/intracytoplasmic sperm injection treatment. https://www.fertstert.org/article/S0015-0282(24)00026-8/fulltext ↩︎
  128. Wu Y, et al. (2021). Ovarian Endometrioma Negatively Impacts Oocyte Quality and Quantity But Not Pregnancy Outcomes in Women Undergoing IVF/ICSI Treatment: A Retrospective Cohort Study. https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.739228/full ↩︎
  129. Iwami N, et al. (2020). New treatment strategy for endometriosis using progestin-primed ovarian stimulation with dienogest: A prospective cohort study, comparison of dienogest versus dydrogesterone. https://www.sciencedirect.com/science/article/abs/pii/S1642431X20303004 ↩︎

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Endometriosis Overview

Endometriosis Overview

Endometriosis is a common yet complex gynecological inflammatory disease characterized by the growth of endometrial-like tissue outside the…. Read more

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