Causes of Teratozoospermia

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By Isareeya Arworn
October 21, 2024March 8, 2022

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Main article: Teratozoospermia Overview

Updated: 21-October-2024

Causes of Teratozoospermia

Known causes of teratozoospermia include:

Genetic defects
Hormone imbalance
Varicoceles
Infection
Obesity
Smoking
Drugs and alcohol
Overheating testicles
Chemicals and heavy metals

Genetic Defects

Genetic defects are a known cause of poor sperm morphology. Specifically, any defects (or mutations) in the following genes:

AK7 (multiple morphological abnormalities of the flagella)
ARMC2 (multiple morphological abnormalities of the flagella)
AURKC (macrozoospermia)
BSCL2 (lipid dysfunction)
CCDC62 (globozoospermia)
CCIN (globozoospermia)
CFAP43, CFAP44, CFAP47, CFAP69, CFAP251 (multiple morphological abnormalities of the flagella)
DNAH1, DNAH6, DNAH11 (multiple morphological abnormalities of the flagella)
DPY19L2 (globozoospermia)
FSIP2 (multiple morphological abnormalities of the flagella)
PICK1 (globozoospermia)
PMFBP1 (globozoospermia)
SPATA6, SPATA16 (globozoospermia)
SUN5 (globozoospermia)
TENT5D (multiple morphological abnormalities)
ZPBP1 (globozoospermia)